Diabetic Alert dogs are increasingly being used to detect low blood sugar before the person is aware of it. Of course there is a huge demand, as diabetes is very widespread. This article is about a trainer in the US, and mentions a report to a scientific conference. It is really important to evaluate training methods, and what factors lead to success in selection and training of assistance dogs.
Positive reinforcement
It's effective, it gets you and your dog thinking...and it's fun!-
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Practical Pet Dog Training Specialty (reward-based)